2w9z: Difference between revisions

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~~[[Image:2w9z.png|left|200px]]~~

===CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN===

===~~CRYSTAL STRUCTURE OF~~ CDK4 ~~IN COMPLEX WITH A D~~-~~TYPE CYCLIN===~~

==Disease==

[[http://www.uniprot.org/uniprot/CDK4_HUMAN CDK4_HUMAN]] Defects in CDK4 are a cause of susceptibility to cutaneous malignant melanoma type 3 (CMM3) [MIM:[http://omim.org/entry/609048 609048]]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.<ref>PMID:7652577</ref><ref>PMID:8528263</ref><ref>PMID:9311594</ref><ref>PMID:9425228</ref>

~~{{ABSTRACT_PUBMED_19237565}}~~

==Function==

[[http://www.uniprot.org/uniprot/CDK4_HUMAN CDK4_HUMAN]] Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.<ref>PMID:9003781</ref><ref>PMID:15241418</ref><ref>PMID:18827403</ref>

==About this Structure==

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==Reference==

[[Category: Cyclin-dependent kinase]]

[[Category: Homo sapiens]]

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@@ Line 1: / Line 1: @@
-[[Image:2w9z.png|left|200px]]
 {{STRUCTURE_2w9z|  PDB=2w9z  |  SCENE=  }}
+===CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN===
+{{ABSTRACT_PUBMED_19237565}}
-===CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN===
+==Disease==
+[[http://www.uniprot.org/uniprot/CDK4_HUMAN CDK4_HUMAN]] Defects in CDK4 are a cause of susceptibility to cutaneous malignant melanoma type 3 (CMM3) [MIM:[http://omim.org/entry/609048 609048]]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.<ref>PMID:7652577</ref><ref>PMID:8528263</ref><ref>PMID:9311594</ref><ref>PMID:9425228</ref>
-{{ABSTRACT_PUBMED_19237565}}
+==Function==
+[[http://www.uniprot.org/uniprot/CDK4_HUMAN CDK4_HUMAN]] Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.<ref>PMID:9003781</ref><ref>PMID:15241418</ref><ref>PMID:18827403</ref>
 ==About this Structure==
@@ Line 15: / Line 17: @@
 ==Reference==
-<ref group="xtra">PMID:019237565</ref><references group="xtra"/>
+<ref group="xtra">PMID:019237565</ref><references group="xtra"/><references/>
 [[Category: Cyclin-dependent kinase]]
 [[Category: Homo sapiens]]