1mx1: Difference between revisions

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[[Image:1mx1.gif|left|200px]]<br /><applet load="1mx1" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1mx1.gif|left|200px]]
caption="1mx1, resolution 2.40&Aring;" />
 
'''Crystal Structure of Human Liver Carboxylesterase in complex with tacrine'''<br />
{{Structure
|PDB= 1mx1 |SIZE=350|CAPTION= <scene name='initialview01'>1mx1</scene>, resolution 2.40&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene> and <scene name='pdbligand=THA:TACRINE'>THA</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1]
|GENE=
}}
 
'''Crystal Structure of Human Liver Carboxylesterase in complex with tacrine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1MX1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=SIA:'>SIA</scene> and <scene name='pdbligand=THA:'>THA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MX1 OCA].  
1MX1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MX1 OCA].  


==Reference==
==Reference==
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition., Bencharit S, Morton CL, Hyatt JL, Kuhn P, Danks MK, Potter PM, Redinbo MR, Chem Biol. 2003 Apr;10(4):341-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12725862 12725862]
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition., Bencharit S, Morton CL, Hyatt JL, Kuhn P, Danks MK, Potter PM, Redinbo MR, Chem Biol. 2003 Apr;10(4):341-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12725862 12725862]
[[Category: Carboxylesterase]]
[[Category: Carboxylesterase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: hydrolase]]
[[Category: hydrolase]]


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