3fhc: Difference between revisions

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[[Image:3fhc.png|left|200px]]
{{STRUCTURE_3fhc|  PDB=3fhc  |  SCENE=  }}  
{{STRUCTURE_3fhc|  PDB=3fhc  |  SCENE=  }}  
===Crystal structure of human Dbp5 in complex with Nup214===
{{ABSTRACT_PUBMED_19219046}}


===Crystal structure of human Dbp5 in complex with Nup214===
==Disease==
[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene.  Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.


{{ABSTRACT_PUBMED_19219046}}
==Function==
[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [[http://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN]] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:019219046</ref><references group="xtra"/>
<ref group="xtra">PMID:019219046</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Conti, E.]]
[[Category: Conti, E.]]

Revision as of 20:25, 24 March 2013

Template:STRUCTURE 3fhc

Crystal structure of human Dbp5 in complex with Nup214

Template:ABSTRACT PUBMED 19219046

Disease

[NU214_HUMAN] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.

Function

[NU214_HUMAN] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [DD19B_HUMAN] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.

About this Structure

3fhc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. von Moeller H, Basquin C, Conti E. The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner. Nat Struct Mol Biol. 2009 Feb 15. PMID:19219046 doi:nsmb.1561

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