1fkh: Difference between revisions

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~~[[Image:1fkh.png|left|200px]]~~

==DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12==

~~{{STRUCTURE_1fkh| PDB=1fkh | SCENE= }}~~

== Structural highlights ==

<table><tr><td colspan='2'>[[1fkh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FKH FirstGlance]. <br>

===DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12===

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SBX:1-CYCLOHEXYL-3-PHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE+CARBOXYLATE'>SBX</scene><br>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fkh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fkh RCSB], [http://www.ebi.ac.uk/pdbsum/1fkh PDBsum]</span></td></tr>

<table>

==~~About this Structure~~==

== Evolutionary Conservation ==

[[1fkh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKH OCA].

[[Image:Consurf_key_small.gif|200px|right]]

Check<jmol>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/1fkh_consurf.spt"</scriptWhenChecked>

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>

<text>to colour the structure by Evolutionary Conservation</text>

</jmolCheckbox>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].

==See Also==

*[[~~Cyclophilin~~|~~Cyclophilin~~]]

*[[FK506 binding protein|FK506 binding protein]]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Bossard, M J.]]

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@@ Line 1: / Line 1: @@
-[[Image:1fkh.png|left|200px]]
+==DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12==
+<StructureSection load='1fkh' size='340' side='right' caption='[[1fkh]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-{{STRUCTURE_1fkh|  PDB=1fkh  |  SCENE=  }}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1fkh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FKH FirstGlance]. <br>
-===DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12===
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SBX:1-CYCLOHEXYL-3-PHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE+CARBOXYLATE'>SBX</scene><br>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fkh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fkh RCSB], [http://www.ebi.ac.uk/pdbsum/1fkh PDBsum]</span></td></tr>
+<table>
-==About this Structure==
+== Evolutionary Conservation ==
-[[1fkh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKH OCA].
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/1fkh_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Cyclophilin|Cyclophilin]]
+*[[FK506 binding protein|FK506 binding protein]]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
 [[Category: Bossard, M J.]]