2fjh: Difference between revisions

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~~[[Image:2fjh.png|left|200px]]~~

===Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF===

===~~Structure~~ of the ~~B20~~-~~4 Fab, a phage derived Fab fragment, in complex with VEGF===~~

==Disease==

[[http://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN]] Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:[http://omim.org/entry/603933 603933]]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

~~{{ABSTRACT_PUBMED_16373345}}~~

==Function==

[[http://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN]] Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.<ref>PMID:11427521</ref><ref>PMID:15520188</ref><ref>PMID:16489009</ref>

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Wiesmann, C.]]

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@@ Line 1: / Line 1: @@
-[[Image:2fjh.png|left|200px]]
 {{STRUCTURE_2fjh|  PDB=2fjh  |  SCENE=  }}
+===Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF===
+{{ABSTRACT_PUBMED_16373345}}
-===Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF===
+==Disease==
+[[http://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN]] Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:[http://omim.org/entry/603933 603933]]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
-{{ABSTRACT_PUBMED_16373345}}
+==Function==
+[[http://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN]] Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.<ref>PMID:11427521</ref><ref>PMID:15520188</ref><ref>PMID:16489009</ref>
 ==About this Structure==
@@ Line 15: / Line 17: @@
 ==Reference==
-<ref group="xtra">PMID:016373345</ref><references group="xtra"/>
+<ref group="xtra">PMID:016373345</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Wiesmann, C.]]