1iyi: Difference between revisions
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{{STRUCTURE_1iyi| PDB=1iyi | SCENE= }} | {{STRUCTURE_1iyi| PDB=1iyi | SCENE= }} | ||
===Crystal structure of hematopoietic prostaglandin D synthase=== | |||
{{ABSTRACT_PUBMED_12627223}} | |||
=== | ==Function== | ||
[[http://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[1iyi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[1iyi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IYI OCA]. | ||
==See Also== | ==See Also== | ||
*[[Glutathione S-transferase|Glutathione S-transferase]] | |||
*[[Prostaglandin D synthase|Prostaglandin D synthase]] | *[[Prostaglandin D synthase|Prostaglandin D synthase]] | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012627223</ref><references group="xtra"/> | <ref group="xtra">PMID:012627223</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Prostaglandin-D synthase]] | [[Category: Prostaglandin-D synthase]] | ||
[[Category: Inoue, T.]] | [[Category: Inoue, T.]] | ||
