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[[Image:3lli.png|left|200px]]
==Sulfhydryl Oxidase Fragment of Human QSOX1==
<StructureSection load='3lli' size='340' side='right' caption='[[3lli]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3lli]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LLI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jr8|1jr8]], [[1jra|1jra]], [[2hj3|2hj3]], [[3gwn|3gwn]], [[3gwl|3gwl]], [[1oqc|1oqc]], [[3llk|3llk]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">QSCN6, QSOX1, UNQ2520/PRO6013 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lli OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lli RCSB], [http://www.ebi.ac.uk/pdbsum/3lli PDBsum]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ll/3lli_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Quiescin sulfhydryl oxidase (QSOX) catalyzes formation of disulfide bonds between cysteine residues in substrate proteins. Human QSOX1 is a multi-domain, monomeric enzyme containing a module related to the single-domain sulfhydryl oxidases of the Erv family. A partial QSOX1 crystal structure reveals a single-chain pseudo-dimer mimicking the quaternary structure of Erv enzymes. However, one pseudo-dimer "subunit" has lost its cofactor and catalytic activity. In QSOX evolution, a further concatenation to a member of the protein disulfide isomerase family resulted in an enzyme capable of both disulfide formation and efficient transfer to substrate proteins.


{{STRUCTURE_3lli|  PDB=3lli  |  SCENE=  }}
QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains.,Alon A, Heckler EJ, Thorpe C, Fass D FEBS Lett. 2010 Apr 16;584(8):1521-5. Epub 2010 Mar 6. PMID:20211621<ref>PMID:20211621</ref>


===Sulfhydryl Oxidase Fragment of Human QSOX1===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_20211621}}
 
==About this Structure==
[[3lli]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LLI OCA].


==See Also==
==See Also==
*[[Sulfhydryl oxidase|Sulfhydryl oxidase]]
*[[Sulfhydryl oxidase|Sulfhydryl oxidase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:020211621</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thiol oxidase]]
[[Category: Thiol oxidase]]
[[Category: Alon, A.]]
[[Category: Alon, A]]
[[Category: Fass, D.]]
[[Category: Fass, D]]
[[Category: Disulfide]]
[[Category: Disulfide]]
[[Category: Fad]]
[[Category: Fad]]
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