1b07: Difference between revisions
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{{STRUCTURE_1b07| PDB=1b07 | SCENE= }} | {{STRUCTURE_1b07| PDB=1b07 | SCENE= }} | ||
===CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR=== | ===CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR=== | ||
{{ABSTRACT_PUBMED_9851931}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE]] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | |||
==About this Structure== | ==About this Structure== | ||
[[1b07]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[1b07]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B07 OCA]. | ||
==See Also== | ==See Also== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:009851931</ref><references group="xtra"/> | <ref group="xtra">PMID:009851931</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Cohen, F E.]] | [[Category: Cohen, F E.]] | ||
[[Category: Lim, W A.]] | [[Category: Lim, W A.]] | ||
Revision as of 08:53, 25 December 2013
CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR
Template:ABSTRACT PUBMED 9851931
Function
[CRK_MOUSE] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
About this Structure
1b07 is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.
See Also
Reference
- Nguyen JT, Turck CW, Cohen FE, Zuckermann RN, Lim WA. Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors. Science. 1998 Dec 11;282(5396):2088-92. PMID:9851931
