1nce: Difference between revisions

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[[Image:1nce.jpg|left|200px]]<br /><applet load="1nce" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1nce.jpg|left|200px]]
caption="1nce, resolution 2.40&Aring;" />
 
'''Crystal structure of a ternary complex of E. coli thymidylate synthase D169C with dUMP and the antifolate CB3717'''<br />
{{Structure
|PDB= 1nce |SIZE=350|CAPTION= <scene name='initialview01'>1nce</scene>, resolution 2.40&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=UMP:2'-DEOXYURIDINE+5'-MONOPHOSPHATE'>UMP</scene> and <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC ACID'>CB3</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE= THYA OR B2827 OR Z4144 OR ECS3684 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Escherichia coli, and Escherichia coli O157:H7])
}}
 
'''Crystal structure of a ternary complex of E. coli thymidylate synthase D169C with dUMP and the antifolate CB3717'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1NCE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli,_and_escherichia_coli_o157:h7 Escherichia coli, and escherichia coli o157:h7] with <scene name='pdbligand=UMP:'>UMP</scene> and <scene name='pdbligand=CB3:'>CB3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCE OCA].  
1NCE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli,_and_escherichia_coli_o157:h7 Escherichia coli, and escherichia coli o157:h7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCE OCA].  


==Reference==
==Reference==
The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity., Birdsall DL, Finer-Moore J, Stroud RM, Protein Eng. 2003 Mar;16(3):229-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12702803 12702803]
The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity., Birdsall DL, Finer-Moore J, Stroud RM, Protein Eng. 2003 Mar;16(3):229-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12702803 12702803]
[[Category: Escherichia coli, and escherichia coli o157:h7]]
[[Category: Escherichia coli, and escherichia coli o157:h7]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein-dump-cofactor analog complex]]
[[Category: protein-dump-cofactor analog complex]]


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