3pin: Difference between revisions
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{{STRUCTURE_3pin| PDB=3pin | SCENE= }} | {{STRUCTURE_3pin| PDB=3pin | SCENE= }} | ||
===Crystal structure of Mxr1 from Saccharomyces cerevisiae in complex with Trx2=== | ===Crystal structure of Mxr1 from Saccharomyces cerevisiae in complex with Trx2=== | ||
{{ABSTRACT_PUBMED_21345799}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TRX2_YEAST TRX2_YEAST]] Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl-hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism. Through its capacity to inactivate the stress response transcription factor YAP1 and its regulator the hydroperoxide stress sensor HYR1, it is involved in feedback regulation of stress response gene expression upon oxidative stress.<ref>PMID:3060034</ref> <ref>PMID:9015301</ref> <ref>PMID:9657146</ref> <ref>PMID:10681558</ref> <ref>PMID:9988687</ref> <ref>PMID:11013218</ref> <ref>PMID:12437921</ref> <ref>PMID:12410842</ref> <ref>PMID:11169096</ref> <ref>PMID:12914955</ref> [[http://www.uniprot.org/uniprot/MSRA_YEAST MSRA_YEAST]] Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Also able to reduce dimethyl sulfoxide (DMSO) as well, with DMS as the product. | |||
==About this Structure== | ==About this Structure== | ||
[[3pin]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3pin]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIN OCA]. | ||
==See Also== | ==See Also== | ||
*[[Thioredoxin|Thioredoxin]] | *[[Thioredoxin|Thioredoxin]] | ||
[[Category: | |||
==Reference== | |||
<ref group="xtra">PMID:021345799</ref><references group="xtra"/><references/> | |||
[[Category: Atcc 18824]] | |||
[[Category: Chen, Y.]] | [[Category: Chen, Y.]] | ||
[[Category: Guo, P C.]] | [[Category: Guo, P C.]] | ||
