2gx9: Difference between revisions

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[[Image:2gx9.png|left|200px]]
==X-ray strucutre of influenza virus NS1 effector domain==
<StructureSection load='2gx9' size='340' side='right' caption='[[2gx9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2gx9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GX9 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene><br>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Segment 8 - NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11309 unidentified influenza virus])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gx9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gx9 RCSB], [http://www.ebi.ac.uk/pdbsum/2gx9 PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The nonstructural protein NS1 of influenza virus is an antagonist of host immune responses and is implicated in virulence. It has two domains, an N-terminal double-stranded RNA-binding domain (RBD) and an effector domain crucial for RBD function, for nuclear export and for sequestering messenger RNA-processing proteins. Here we present the crystallographic structure of the effector domain, which has a novel fold and suggests mechanisms for increased virulence in H5N1 strains.


{{STRUCTURE_2gx9|  PDB=2gx9  |  SCENE=  }}
X-ray structure of influenza virus NS1 effector domain.,Bornholdt ZA, Prasad BV Nat Struct Mol Biol. 2006 Jun;13(6):559-60. Epub 2006 May 21. PMID:16715094<ref>PMID:16715094</ref>


===X-ray strucutre of influenza virus NS1 effector domain===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_16715094}}
 
==About this Structure==
[[2gx9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GX9 OCA].


==See Also==
==See Also==
*[[Nonstructural protein|Nonstructural protein]]
*[[Nonstructural protein|Nonstructural protein]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:016715094</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Unidentified influenza virus]]
[[Category: Unidentified influenza virus]]
[[Category: Bornholdt, Z A.]]
[[Category: Bornholdt, Z A.]]
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