3qj4: Difference between revisions
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{{STRUCTURE_3qj4| PDB=3qj4 | SCENE= }} | {{STRUCTURE_3qj4| PDB=3qj4 | SCENE= }} | ||
===Crystal structure of Human Renalase (isoform 1)=== | ===Crystal structure of Human Renalase (isoform 1)=== | ||
{{ABSTRACT_PUBMED_21699903}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RNLS_HUMAN RNLS_HUMAN]] Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity.<ref>PMID:15841207</ref> <ref>PMID:17385068</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3qj4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJ4 OCA]. | [[3qj4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJ4 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021699903</ref><references group="xtra"/> | <ref group="xtra">PMID:021699903</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Aliverti, A.]] | [[Category: Aliverti, A.]] | ||
