1tf0: Difference between revisions
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{{STRUCTURE_1tf0| PDB=1tf0 | SCENE= }} | {{STRUCTURE_1tf0| PDB=1tf0 | SCENE= }} | ||
===Crystal structure of the GA module complexed with human serum albumin=== | |||
{{ABSTRACT_PUBMED_15269208}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref><ref>PMID:9589637</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> [[http://www.uniprot.org/uniprot/PAB_PEPMA PAB_PEPMA]] Binds serum albumin. | |||
==About this Structure== | ==About this Structure== | ||
[[1tf0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[1tf0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Finegoldia_magna_atcc_29328 Finegoldia magna atcc 29328] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF0 OCA]. | ||
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:015269208</ref><references group="xtra"/> | <ref group="xtra">PMID:015269208</ref><references group="xtra"/><references/> | ||
[[Category: Finegoldia magna]] | [[Category: Finegoldia magna atcc 29328]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bjorck, L.]] | [[Category: Bjorck, L.]] | ||
