2o21: Difference between revisions
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{{STRUCTURE_2o21| PDB=2o21 | SCENE= }} | {{STRUCTURE_2o21| PDB=2o21 | SCENE= }} | ||
===Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand=== | |||
{{ABSTRACT_PUBMED_17256834}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> | |||
==About this Structure== | ==About this Structure== | ||
| Line 14: | Line 16: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017256834</ref><references group="xtra"/> | <ref group="xtra">PMID:017256834</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Belli, B A.]] | [[Category: Belli, B A.]] | ||
