1nox: Difference between revisions
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[[Image:1nox.gif|left|200px]] | [[Image:1nox.gif|left|200px]] | ||
'''NADH OXIDASE FROM THERMUS THERMOPHILUS''' | {{Structure | ||
|PDB= 1nox |SIZE=350|CAPTION= <scene name='initialview01'>1nox</scene>, resolution 1.59Å | |||
|SITE= <scene name='pdbsite=COF:Cofactor'>COF</scene> | |||
|LIGAND= <scene name='pdbligand=FMN:FLAVIN MONONUCLEOTIDE'>FMN</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/NADH_dehydrogenase NADH dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.99.3 1.6.99.3] | |||
|GENE= | |||
}} | |||
'''NADH OXIDASE FROM THERMUS THERMOPHILUS''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1NOX is a [ | 1NOX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NOX OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of NADH oxidase from Thermus thermophilus., Hecht HJ, Erdmann H, Park HJ, Sprinzl M, Schmid RD, Nat Struct Biol. 1995 Dec;2(12):1109-14. PMID:[http:// | Crystal structure of NADH oxidase from Thermus thermophilus., Hecht HJ, Erdmann H, Park HJ, Sprinzl M, Schmid RD, Nat Struct Biol. 1995 Dec;2(12):1109-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8846223 8846223] | ||
[[Category: NADH dehydrogenase]] | [[Category: NADH dehydrogenase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Sprinzl, M.]] | [[Category: Sprinzl, M.]] | ||
[[Category: FMN]] | [[Category: FMN]] | ||
[[Category: flavoenzyme ]] | [[Category: flavoenzyme]] | ||
[[Category: flavoprotein fmn]] | [[Category: flavoprotein fmn]] | ||
[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
[[Category: thermophile]] | [[Category: thermophile]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:59:42 2008'' | ||
Revision as of 10:59, 20 March 2008
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| 1nox, resolution 1.59Å | |||||||||||||
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| Sites: | COF | ||||||||||||
| Ligands: | FMN | ||||||||||||
| Activity: | NADH dehydrogenase, with EC number 1.6.99.3 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
NADH OXIDASE FROM THERMUS THERMOPHILUS
Overview
The crystal structures of the flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) containing isoforms of NADH oxidase from Thermus thermophilus have been determined by isomorphous and molecular replacement and refined to 2.3 A and 1.6 A resolution with R-values of 18.5% and 18.6% respectively. The structure of the homodimeric enzyme consists of a central 4-stranded antiparallel beta-sheet covered by helices, a more flexible domain formed by two helices, and a C-terminal excursion connecting the subunits. The active sites are located in a deep cleft between the subunits. The binding site of the flavin cofactor lacks the common nucleotide binding fold and is different from the FMN binding site found in flavodoxins.
About this Structure
1NOX is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.
Reference
Crystal structure of NADH oxidase from Thermus thermophilus., Hecht HJ, Erdmann H, Park HJ, Sprinzl M, Schmid RD, Nat Struct Biol. 1995 Dec;2(12):1109-14. PMID:8846223
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