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[[Image:2ljc.png|left|200px]]
==Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine==
<StructureSection load='2ljc' size='340' side='right' caption='[[2ljc]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/taiwan/70061/2006) Influenza b virus (b/taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJC FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene><br>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rlf|2rlf]], [[2kix|2kix]], [[2ljb|2ljb]], [[2kwx|2kwx]]</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=529646 Influenza B virus (B/Taiwan/70061/2006)])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [http://www.ebi.ac.uk/pdbsum/2ljc PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The M2 channel of influenza A is a target of the adamantane family antiviral drugs. Two different drug-binding sites have been reported: one inside the pore, and the other is a lipid-facing pocket. A previous study showed that a chimera of M2 variants from influenza A and B that contains only the pore-binding site is sensitive to amantadine inhibition, suggesting that the primary site of inhibition is inside the pore. To obtain atomic details of channel-drug interaction, we determined the structures of the chimeric channel with and without rimantadine. Inside the channel and near the N-terminal end, methyl groups of Val27 and Ala30 from four subunits form a hydrophobic pocket around the adamantane, and the drug amino group appears to be in polar contact with the backbone oxygen of Ala30. The structures also reveal differences between the drug-bound and -unbound states of the channel that can explain drug resistance.


{{STRUCTURE_2ljc|  PDB=2ljc  |  SCENE=  }}
Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses.,Pielak RM, Oxenoid K, Chou JJ Structure. 2011 Nov 9;19(11):1655-63. PMID:22078564<ref>PMID:22078564</ref>


===Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_22078564}}
 
==About this Structure==
[[2ljc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/taiwan/70061/2006) Influenza b virus (b/taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA].


==See Also==
==See Also==
*[[M2 protein|M2 protein]]
*[[M2 protein|M2 protein]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:022078564</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Chou, J J.]]
[[Category: Chou, J J.]]
[[Category: Oxenoid, K.]]
[[Category: Oxenoid, K.]]
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