1adw: Difference between revisions
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==Overview== | ==Overview== | ||
The structure of pseudoazurin from Thiosphaera pantotropha has been, determined and compared to structures of both soluble and membrane-bound, periplasmic redox proteins. The results show a matching set of unipolar, but promiscuous, docking motifs based on a positive hydrophobic surface, patch on the electron shuttle proteins pseudoazurin and cytochrome c550, and a negative hydrophobic patch on the surface of their known redox, partners. The observed electrostatic handedness is argued to be associated, with the charge-asymmetry of the membrane-bound components of the redox, chain due to von Heijne's 'positives-inside' principle. We propose a, 'positives-in-between' rule for electron shuttle proteins, and expect a, negative hydrophobic patch to be present on both the highest and lowest, . | The structure of pseudoazurin from Thiosphaera pantotropha has been, determined and compared to structures of both soluble and membrane-bound, periplasmic redox proteins. The results show a matching set of unipolar, but promiscuous, docking motifs based on a positive hydrophobic surface, patch on the electron shuttle proteins pseudoazurin and cytochrome c550, and a negative hydrophobic patch on the surface of their known redox, partners. The observed electrostatic handedness is argued to be associated, with the charge-asymmetry of the membrane-bound components of the redox, chain due to von Heijne's 'positives-inside' principle. We propose a, 'positives-in-between' rule for electron shuttle proteins, and expect a, negative hydrophobic patch to be present on both the highest and lowest, redox potential species in a series of electron carriers. | ||
==About this Structure== | ==About this Structure== | ||
1ADW is a | 1ADW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Paracoccus_pantotrophus Paracoccus pantotrophus] with CU as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Sites: CUA and CUB. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ADW OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: electron transport]] | [[Category: electron transport]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 12:37:52 2007'' | ||
