3kc4: Difference between revisions

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[[Image:3kc4.png|left|200px]]
==Ribosome-SecY complex. This entry 3KC4 contains 30S ribosomal subnit. The 50S ribosomal subunit can be found in PDB entry 3KCR==
<StructureSection load='3kc4' size='340' side='right' caption='[[3kc4]], [[Resolution|resolution]] 9.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3kc4]] is a 21 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KC4 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bo0|3bo0]], [[3bo1|3bo1]], [[3kcr|3kcr]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kc4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kc4 RCSB], [http://www.ebi.ac.uk/pdbsum/3kc4 PDBsum]</span></td></tr>
<table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/3kc4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
During protein synthesis, it is often necessary for the ribosome to form a complex with a membrane-bound channel, the SecY/Sec61 complex, in order to translocate nascent proteins across a cellular membrane. Structural data on the ribosome-channel complex are currently limited to low-resolution cryo-electron microscopy maps, including one showing a bacterial ribosome bound to a monomeric SecY complex. Using that map along with available atomic-level models of the ribosome and SecY, we have determined, through molecular dynamics flexible fitting (MDFF), an atomic-resolution model of the ribosome-channel complex. We characterized computationally the sites of ribosome-SecY interaction within the complex and determined the effect of ribosome binding on the SecY channel. We also constructed a model of a ribosome in complex with a SecY dimer by adding a second copy of SecY to the MDFF-derived model. The study involved 2.7-million-atom simulations over altogether nearly 50 ns.


{{STRUCTURE_3kc4|  PDB=3kc4  |  SCENE=  }}
Regulation of the protein-conducting channel by a bound ribosome.,Gumbart J, Trabuco LG, Schreiner E, Villa E, Schulten K Structure. 2009 Nov 11;17(11):1453-64. PMID:19913480<ref>PMID:19913480</ref>


===Ribosome-SecY complex. This entry 3KC4 contains 30S ribosomal subnit. The 50S ribosomal subunit can be found in PDB entry 3KCR===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_19913480}}
 
==About this Structure==
[[3kc4]] is a 21 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KC4 OCA].


==See Also==
==See Also==
*[[Ribosomal protein S10|Ribosomal protein S10]]
*[[Ribosomal protein S11|Ribosomal protein S11]]
*[[Ribosomal protein S12|Ribosomal protein S12]]
*[[Ribosomal protein S13|Ribosomal protein S13]]
*[[Ribosomal protein S14|Ribosomal protein S14]]
*[[Ribosomal protein S15|Ribosomal protein S15]]
*[[Ribosomal protein S16|Ribosomal protein S16]]
*[[Ribosomal protein S17|Ribosomal protein S17]]
*[[Ribosomal protein S18|Ribosomal protein S18]]
*[[Ribosomal protein S19|Ribosomal protein S19]]
*[[Ribosomal protein S2|Ribosomal protein S2]]
*[[Ribosomal protein S2|Ribosomal protein S2]]
*[[Ribosomal protein S20|Ribosomal protein S20]]
*[[Ribosomal protein S21|Ribosomal protein S21]]
*[[Ribosomal protein S21|Ribosomal protein S21]]
*[[Ribosomal protein S3|Ribosomal protein S3]]
*[[Ribosomal protein S3|Ribosomal protein S3]]
*[[Ribosomal protein S4|Ribosomal protein S4]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosomal protein S5|Ribosomal protein S5]]
== References ==
*[[Ribosomal protein S6|Ribosomal protein S6]]
<references/>
*[[Ribosomal protein S7|Ribosomal protein S7]]
__TOC__
*[[Ribosomal protein S8|Ribosomal protein S8]]
</StructureSection>
*[[Ribosomal protein S9|Ribosomal protein S9]]
 
==Reference==
<ref group="xtra">PMID:019913480</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli k-12]]
[[Category: Escherichia coli k-12]]
Retrieved from "https://proteopedia.org/3kc4"