1sdb: Difference between revisions

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[[~~Image~~:1sdb.~~png|left|200px~~]]

==PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN==

== Structural highlights ==

<table><tr><td colspan='2'>[[1sdb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SDB FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sdb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sdb RCSB], [http://www.ebi.ac.uk/pdbsum/1sdb PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures that it circulates and exerts its physiological functions in vivo as a monomer. The crystal structure of monomeric porcine desB1-B2 despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has been determined at 1.65 A resolution using the molecular replacement method. A structural comparison between DesB1-2 DPI and 2Zn insulin reveals that the conformation of DesB1-2 DPI is more similar to molecule I than molecule II of 2Zn insulin. The remarkable conformational difference between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30) insulin (DPI) indicates that the residue B25-Phe possesses great flexibility and mobility.

~~{{STRUCTURE_1sdb| PDB=1sdb | SCENE= }}~~

Structure of monomeric porcine DesB1-B2 despentapeptide (B26-B30) insulin at 1.65 A resolution.,Diao JS, Wan ZL, Chang WR, Liang DC Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):507-12. PMID:15299880<ref>PMID:15299880</ref>

~~===PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_15299880}}~~

~~==About this Structure==~~

~~[[1sdb]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Sus_scrofa Sus scrofa]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=1SDB OCA].~~

==See Also==

*[[Molecular Playground/Insulin|Molecular Playground/Insulin]]

== References ==

==~~Reference~~==

<~~ref group="xtra">PMID:015299880<~~/~~ref~~><~~references group="xtra"~~/>

__TOC__

</StructureSection>

[[Category: Sus scrofa]]

[[Category: Diao, J S.]]

[[Category: Liang, D C.]]

[[Category: Hormone]]

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@@ Line 1: / Line 1: @@
-[[Image:1sdb.png|left|200px]]
+==PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN==
+<StructureSection load='1sdb' size='340' side='right' caption='[[1sdb]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1sdb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SDB FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sdb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sdb RCSB], [http://www.ebi.ac.uk/pdbsum/1sdb PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures that it circulates and exerts its physiological functions in vivo as a monomer. The crystal structure of monomeric porcine desB1-B2 despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has been determined at 1.65 A resolution using the molecular replacement method. A structural comparison between DesB1-2 DPI and 2Zn insulin reveals that the conformation of DesB1-2 DPI is more similar to molecule I than molecule II of 2Zn insulin. The remarkable conformational difference between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30) insulin (DPI) indicates that the residue B25-Phe possesses great flexibility and mobility.
-{{STRUCTURE_1sdb|  PDB=1sdb  |  SCENE=  }}
+Structure of monomeric porcine DesB1-B2 despentapeptide (B26-B30) insulin at 1.65 A resolution.,Diao JS, Wan ZL, Chang WR, Liang DC Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):507-12. PMID:15299880<ref>PMID:15299880</ref>
-===PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_15299880}}
-==About this Structure==
-[[1sdb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SDB OCA].
 ==See Also==
 *[[Molecular Playground/Insulin|Molecular Playground/Insulin]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:015299880</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Sus scrofa]]
 [[Category: Diao, J S.]]
 [[Category: Liang, D C.]]
 [[Category: Hormone]]