2bzw: Difference between revisions
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{{STRUCTURE_2bzw| PDB=2bzw | SCENE= }} | {{STRUCTURE_2bzw| PDB=2bzw | SCENE= }} | ||
===The crystal structure of BCL-XL in complex with full-length BAD=== | |||
=== | ==Function== | ||
[[http://www.uniprot.org/uniprot/B2CL1_MOUSE B2CL1_MOUSE]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:9390687</ref> Isoform Bcl-X(S) promotes apoptosis (By similarity).<ref>PMID:9390687</ref> [[http://www.uniprot.org/uniprot/BAD_MOUSE BAD_MOUSE]] Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. | |||
==About this Structure== | ==About this Structure== | ||
[[2bzw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[2bzw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZW OCA]. | ||
==See Also== | ==See Also== | ||
*[[Bcl-2|Bcl-2]] | *[[Bcl-2|Bcl-2]] | ||
[[Category: | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Lk3 transgenic mice]] | |||
[[Category: Han, W D.]] | [[Category: Han, W D.]] | ||
[[Category: Kim, K J.]] | [[Category: Kim, K J.]] | ||
