1nyd: Difference between revisions
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[[Image:1nyd.gif|left|200px]] | [[Image:1nyd.gif|left|200px]] | ||
'''Solution structure of DNA quadruplex GCGGTGGAT''' | {{Structure | ||
|PDB= 1nyd |SIZE=350|CAPTION= <scene name='initialview01'>1nyd</scene> | |||
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'''Solution structure of DNA quadruplex GCGGTGGAT''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1NYD is a [ | 1NYD is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYD OCA]. | ||
==Reference== | ==Reference== | ||
Association of DNA quadruplexes through G:C:G:C tetrads. Solution structure of d(GCGGTGGAT)., Webba da Silva M, Biochemistry. 2003 Dec 16;42(49):14356-65. PMID:[http:// | Association of DNA quadruplexes through G:C:G:C tetrads. Solution structure of d(GCGGTGGAT)., Webba da Silva M, Biochemistry. 2003 Dec 16;42(49):14356-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14661946 14661946] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Silva, M Webba da.]] | [[Category: Silva, M Webba da.]] | ||
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[[Category: quadruplex]] | [[Category: quadruplex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:03:17 2008'' | ||
Revision as of 11:03, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Solution structure of DNA quadruplex GCGGTGGAT
Overview
The structure formed by the DNA sequence d(GCGGTGGAT) in a 100 mM Na(+) solution has been determined using molecular dynamics calculations constrained by distance and dihedral restraints derived from NMR experiments performed at isotopic natural abundance. The sequence folds into a dimer of dimers. Each symmetry-related half contains two parallel stranded G:G:G:G tetrads flanked by an A:A mismatch and by four-stranded G:C:G:C tetrads. Each of the two juxtaposed G:C:G:C tetrads is composed of alternating antiparallel strands from the two halves of the dimer. For each single strand, a thymine intersperses a double chain reversal connecting the juxtaposed G:G:G:G tetrads. This architecture has potential implications in genetic recombination. It suggests a pathway for oligomerization involving association of quadruplex entities through GpC steps.
About this Structure
1NYD is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Association of DNA quadruplexes through G:C:G:C tetrads. Solution structure of d(GCGGTGGAT)., Webba da Silva M, Biochemistry. 2003 Dec 16;42(49):14356-65. PMID:14661946
Page seeded by OCA on Thu Mar 20 13:03:17 2008
