1o04: Difference between revisions

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[[Image:1o04.gif|left|200px]]<br /><applet load="1o04" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1o04.gif|left|200px]]
caption="1o04, resolution 1.42&Aring;" />
 
'''Cys302Ser mutant of human mitochondrial aldehyde dehydrogenase complexed with NAD+ and Mg2+'''<br />
{{Structure
|PDB= 1o04 |SIZE=350|CAPTION= <scene name='initialview01'>1o04</scene>, resolution 1.42&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=GAI:GUANIDINE'>GAI</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(NAD(+)) Aldehyde dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.3 1.2.1.3]
|GENE= ALDH2 OR ALDM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Cys302Ser mutant of human mitochondrial aldehyde dehydrogenase complexed with NAD+ and Mg2+'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1O04 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=NAD:'>NAD</scene>, <scene name='pdbligand=GAI:'>GAI</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(NAD(+)) Aldehyde dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.3 1.2.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O04 OCA].  
1O04 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O04 OCA].  


==Reference==
==Reference==
Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase., Perez-Miller SJ, Hurley TD, Biochemistry. 2003 Jun 17;42(23):7100-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12795606 12795606]
Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase., Perez-Miller SJ, Hurley TD, Biochemistry. 2003 Jun 17;42(23):7100-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12795606 12795606]
[[Category: Aldehyde dehydrogenase (NAD(+))]]
[[Category: Aldehyde dehydrogenase (NAD(+))]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: nadh]]
[[Category: nadh]]


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