1o0d: Difference between revisions

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[[Image:1o0d.jpg|left|200px]]<br /><applet load="1o0d" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1o0d.jpg|left|200px]]
caption="1o0d, resolution 2.44&Aring;" />
 
'''Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor'''<br />
{{Structure
|PDB= 1o0d |SIZE=350|CAPTION= <scene name='initialview01'>1o0d</scene>, resolution 2.44&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=163:(2-{2-[(5-CARBAMIMIDOYL-1-METHYL-1H-PYRROL-2-YLMETHYL)-CARBAMOYL]-PYRROL-1-YL}- 1-CYCLOHEXYLMETHYL-2-OXO-ETHYLAMINO)-ACETIC ACID'>163</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]
|GENE= F2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1O0D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=163:'>163</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0D OCA].  
1O0D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0D OCA].  


==Reference==
==Reference==
D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety., Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2029-33. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12781189 12781189]
D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety., Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2029-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12781189 12781189]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: ternary complex; thrombin/active-site inhibitor/exo-site inhibitor]]
[[Category: ternary complex; thrombin/active-site inhibitor/exo-site inhibitor]]


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