1o23: Difference between revisions

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[[Image:1o23.jpg|left|200px]]<br /><applet load="1o23" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1o23.jpg|left|200px]]
caption="1o23, resolution 2.32&Aring;" />
 
'''CRYSTAL STRUCTURE OF LACTOSE SYNTHASE IN THE PRESENCE OF UDP-GLUCOSE'''<br />
{{Structure
|PDB= 1o23 |SIZE=350|CAPTION= <scene name='initialview01'>1o23</scene>, resolution 2.32&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=GUD:GLUCOSE-URIDINE-C1,5'-DIPHOSPHATE'>GUD</scene>, <scene name='pdbligand=UDP:URIDINE-5'-DIPHOSPHATE'>UDP</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene> and <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC ACID'>MES</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/N-acetyllactosamine_synthase N-acetyllactosamine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.90 2.4.1.90]
|GENE= LALBA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), BETA1,4-GALACTOSYLTRANSFERASE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])
}}
 
'''CRYSTAL STRUCTURE OF LACTOSE SYNTHASE IN THE PRESENCE OF UDP-GLUCOSE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1O23 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=MN:'>MN</scene>, <scene name='pdbligand=GUD:'>GUD</scene>, <scene name='pdbligand=UDP:'>UDP</scene>, <scene name='pdbligand=PG4:'>PG4</scene> and <scene name='pdbligand=MES:'>MES</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure supersedes the now removed PDB entries 1NT7 and 1JNC. Active as [http://en.wikipedia.org/wiki/N-acetyllactosamine_synthase N-acetyllactosamine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.90 2.4.1.90] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O23 OCA].  
1O23 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entries 1NT7 and 1JNC. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O23 OCA].  


==Reference==
==Reference==
alpha-Lactalbumin (LA) stimulates milk beta-1,4-galactosyltransferase I (beta 4Gal-T1) to transfer glucose from UDP-glucose to N-acetylglucosamine. Crystal structure of beta 4Gal-T1 x LA complex with UDP-Glc., Ramakrishnan B, Shah PS, Qasba PK, J Biol Chem. 2001 Oct 5;276(40):37665-71. Epub 2001 Aug 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11485999 11485999]
alpha-Lactalbumin (LA) stimulates milk beta-1,4-galactosyltransferase I (beta 4Gal-T1) to transfer glucose from UDP-glucose to N-acetylglucosamine. Crystal structure of beta 4Gal-T1 x LA complex with UDP-Glc., Ramakrishnan B, Shah PS, Qasba PK, J Biol Chem. 2001 Oct 5;276(40):37665-71. Epub 2001 Aug 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11485999 11485999]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: alpha-lactalbumin; beta]]
[[Category: alpha-lactalbumin; beta]]


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