3j0s: Difference between revisions
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[[ | ==Remodeling of actin filaments by ADF cofilin proteins== | ||
<StructureSection load='3j0s' size='340' side='right' caption='[[3j0s]], [[Resolution|resolution]] 9.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3j0s]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J0S FirstGlance]. <br> | |||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CFL1, CFL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j0s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j0s RCSB], [http://www.ebi.ac.uk/pdbsum/3j0s PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACTB_CHICK ACTB_CHICK]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Cofilin/ADF proteins play key roles in the dynamics of actin, one of the most abundant and highly conserved eukaryotic proteins. We used cryoelectron microscopy to generate a 9-A resolution three-dimensional reconstruction of cofilin-decorated actin filaments, the highest resolution achieved for a complex of F-actin with an actin-binding protein. We show that the cofilin-induced change in the filament twist is due to a unique conformation of the actin molecule unrelated to any previously observed state. The changes between the actin protomer in naked F-actin and in the actin-cofilin filament are greater than the conformational changes between G- and F-actin. Our results show the structural plasticity of actin, suggest that other actin-binding proteins may also induce large but different conformational changes, and show that F-actin cannot be described by a single molecular model. | |||
Remodeling of actin filaments by ADF/cofilin proteins.,Galkin VE, Orlova A, Kudryashov DS, Solodukhin A, Reisler E, Schroder GF, Egelman EH Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20568-72. Epub 2011 Dec 7. PMID:22158895<ref>PMID:22158895</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
*[[Actin|Actin]] | *[[Actin|Actin]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Egelman, E H | [[Category: Egelman, E H]] | ||
[[Category: Galkin, V E | [[Category: Galkin, V E]] | ||
[[Category: Kudryashov, D S | [[Category: Kudryashov, D S]] | ||
[[Category: Orlova, A | [[Category: Orlova, A]] | ||
[[Category: Reisler, E | [[Category: Reisler, E]] | ||
[[Category: Schroeder, G F | [[Category: Schroeder, G F]] | ||
[[Category: Solodukhin, A | [[Category: Solodukhin, A]] | ||
[[Category: Contractile protein-actin binding protein complex]] | [[Category: Contractile protein-actin binding protein complex]] | ||
[[Category: Contractile protein-protein binding complex]] | [[Category: Contractile protein-protein binding complex]] | ||
[[Category: Helical polymer]] | [[Category: Helical polymer]] | ||
Revision as of 21:16, 25 December 2014
Remodeling of actin filaments by ADF cofilin proteins
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