3iu3: Difference between revisions
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{{STRUCTURE_3iu3| PDB=3iu3 | SCENE= }} | {{STRUCTURE_3iu3| PDB=3iu3 | SCENE= }} | ||
===Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain=== | |||
{{ABSTRACT_PUBMED_20032294}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/IL2RA_HUMAN IL2RA_HUMAN]] Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:[http://omim.org/entry/601942 601942]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:17676041</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IL2RA_HUMAN IL2RA_HUMAN]] Receptor for interleukin-2. | |||
==About this Structure== | ==About this Structure== | ||
| Line 11: | Line 13: | ||
==See Also== | ==See Also== | ||
*[[Interleukin receptor|Interleukin receptor]] | *[[Interleukin receptor|Interleukin receptor]] | ||
*[[Monoclonal Antibody|Monoclonal Antibody]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020032294</ref><references group="xtra"/> | <ref group="xtra">PMID:020032294</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ding, J.]] | [[Category: Ding, J.]] | ||
Revision as of 04:40, 25 March 2013
Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain
Template:ABSTRACT PUBMED 20032294
Disease
[IL2RA_HUMAN] Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.[1]
Function
[IL2RA_HUMAN] Receptor for interleukin-2.
About this Structure
3iu3 is a 9 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Du J, Yang H, Zhang D, Wang J, Guo H, Peng B, Guo Y, Ding J. Structural basis for the blockage of IL-2 signaling by therapeutic antibody basiliximab. J Immunol. 2010 Feb 1;184(3):1361-8. Epub 2009 Dec 23. PMID:20032294 doi:10.4049/jimmunol.0903178
- ↑ Lowe CE, Cooper JD, Brusko T, Walker NM, Smyth DJ, Bailey R, Bourget K, Plagnol V, Field S, Atkinson M, Clayton DG, Wicker LS, Todd JA. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet. 2007 Sep;39(9):1074-82. Epub 2007 Aug 5. PMID:17676041 doi:10.1038/ng2102
