1im3: Difference between revisions

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~~[[Image:1im3.png|left|200px]]~~

===Crystal Structure of the human cytomegalovirus protein US2 bound to the MHC class I molecule HLA-A2/tax===

===~~Crystal Structure~~ of the ~~human cytomegalovirus protein US2 bound~~ to ~~the MHC class I molecule HLA~~-A2/~~tax===~~

==Disease==

[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:19284997</ref>

~~{{ABSTRACT_PUBMED_11391001}}~~

==Function==

[[http://www.uniprot.org/uniprot/US02_HCMVA US02_HCMVA]] Early protein that redirects newly synthesized MHC class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction. In consequence, infected cells are masked for immune recognition by cytotoxic T lymphocytes. Seems so far to be specific for HLA-A, HLA-B, and HFE loci products. Does not interact with HLA-DR or HLA-DM.<ref>PMID:8945469</ref><ref>PMID:16098592</ref> [[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

==About this Structure==

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==See Also==

*[[Beta-2 microglobulin|Beta-2 microglobulin]]

*[[Effect of HCMV on Major Histocompatibility Complex Class I|Effect of HCMV on Major Histocompatibility Complex Class I]]

*[[Major histocompatibility complex|Major histocompatibility complex]]

==Reference==

[[Category: Homo sapiens]]

[[Category: Human herpesvirus 5]]

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@@ Line 1: / Line 1: @@
-[[Image:1im3.png|left|200px]]
 {{STRUCTURE_1im3|  PDB=1im3  |  SCENE=  }}
+===Crystal Structure of the human cytomegalovirus protein US2 bound to the MHC class I molecule HLA-A2/tax===
+{{ABSTRACT_PUBMED_11391001}}
-===Crystal Structure of the human cytomegalovirus protein US2 bound to the MHC class I molecule HLA-A2/tax===
+==Disease==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:19284997</ref>
-{{ABSTRACT_PUBMED_11391001}}
+==Function==
+[[http://www.uniprot.org/uniprot/US02_HCMVA US02_HCMVA]] Early protein that redirects newly synthesized MHC class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction. In consequence, infected cells are masked for immune recognition by cytotoxic T lymphocytes. Seems so far to be specific for HLA-A, HLA-B, and HFE loci products. Does not interact with HLA-DR or HLA-DM.<ref>PMID:8945469</ref><ref>PMID:16098592</ref> [[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
 ==About this Structure==
@@ Line 12: / Line 14: @@
 ==See Also==
 *[[Beta-2 microglobulin|Beta-2 microglobulin]]
+*[[Effect of HCMV on Major Histocompatibility Complex Class I|Effect of HCMV on Major Histocompatibility Complex Class I]]
 *[[Major histocompatibility complex|Major histocompatibility complex]]
 ==Reference==
-<ref group="xtra">PMID:011391001</ref><references group="xtra"/>
+<ref group="xtra">PMID:011391001</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Human herpesvirus 5]]