2ano: Difference between revisions
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{{STRUCTURE_2ano| PDB=2ano | SCENE= }} | {{STRUCTURE_2ano| PDB=2ano | SCENE= }} | ||
===Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17=== | ===Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17=== | ||
{{ABSTRACT_PUBMED_17125251}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
==About this Structure== | ==About this Structure== | ||
[[2ano]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[2ano]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANO OCA]. | ||
==See Also== | ==See Also== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017125251</ref>< | <ref group="xtra">PMID:017125251</ref><references group="xtra"/><references/> | ||
[[Category: Bacillus coli migula 1895]] | |||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Brown, E D.]] | [[Category: Brown, E D.]] | ||
[[Category: Daigle, D M.]] | [[Category: Daigle, D M.]] | ||
Revision as of 11:42, 20 November 2013
Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17
Template:ABSTRACT PUBMED 17125251
Function
[DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this Structure
2ano is a 1 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895. Full crystallographic information is available from OCA.
See Also
Reference
- Summerfield RL, Daigle DM, Mayer S, Mallik D, Hughes DW, Jackson SG, Sulek M, Organ MG, Brown ED, Junop MS. A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region. J Med Chem. 2006 Nov 30;49(24):6977-86. PMID:17125251 doi:10.1021/jm060570v
