1o5r: Difference between revisions

Line 1:

[[Image:1o5r.jpg|left|200px]]~~<br /><applet load~~="1o5r~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1o5r.jpg|left|200px]]

~~caption="~~1o5r, resolution 2.35Å" />

'''Crystal structure of adenosine deaminase complexed with a potent inhibitor'''~~<br />~~

{{Structure

|PDB= 1o5r |SIZE=350|CAPTION= <scene name='initialview01'>1o5r</scene>, resolution 2.35Å

|SITE=

|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=FR9:1-[(1R)-3-(6-{[(BENZYLAMINO)CARBONYL]AMINO}-1H-INDOL-1-YL)-1-(HYDROXYMETHYL)PROPYL]-1H-IMIDAZOLE-4-CARBOXAMIDE'>FR9</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Adenosine_deaminase Adenosine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.4 3.5.4.4]

|GENE=

}}

'''Crystal structure of adenosine deaminase complexed with a potent inhibitor'''

==Overview==

Line 7:

Line 16:

==About this Structure==

1O5R is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus~~] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=FR9:'>FR9</scene> as [http://en.wikipedia.org/wiki/ligands ligands~~]. ~~Active as [http://en.wikipedia.org/wiki/Adenosine_deaminase Adenosine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.4 3.5.4.4]~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5R OCA].

1O5R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5R OCA].

==Reference==

Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors., Terasaka T, Kinoshita T, Kuno M, Seki N, Tanaka K, Nakanishi I, J Med Chem. 2004 Jul 15;47(15):3730-43. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~15239652 15239652]

Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors., Terasaka T, Kinoshita T, Kuno M, Seki N, Tanaka K, Nakanishi I, J Med Chem. 2004 Jul 15;47(15):3730-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15239652 15239652]

[[Category: Adenosine deaminase]]

[[Category: Bos taurus]]

Line 20:

Line 29:

[[Category: zinc]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 14~~:13:45 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:06:10 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1o5r.jpg|left|200px]]<br /><applet load="1o5r" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1o5r.jpg|left|200px]]
-caption="1o5r, resolution 2.35&Aring;" />
-'''Crystal structure of adenosine deaminase complexed with a potent inhibitor'''<br />
+ {{Structure
+|PDB= 1o5r |SIZE=350|CAPTION= <scene name='initialview01'>1o5r</scene>, resolution 2.35&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=FR9:1-[(1R)-3-(6-{[(BENZYLAMINO)CARBONYL]AMINO}-1H-INDOL-1-YL)-1-(HYDROXYMETHYL)PROPYL]-1H-IMIDAZOLE-4-CARBOXAMIDE'>FR9</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Adenosine_deaminase Adenosine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.4 3.5.4.4]
+|GENE=
+}}
+'''Crystal structure of adenosine deaminase complexed with a potent inhibitor'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-O5R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=FR9:'>FR9</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenosine_deaminase Adenosine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.4 3.5.4.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5R OCA].
+O5R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5R OCA].
 ==Reference==
-Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors., Terasaka T, Kinoshita T, Kuno M, Seki N, Tanaka K, Nakanishi I, J Med Chem. 2004 Jul 15;47(15):3730-43. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15239652 15239652]
+Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors., Terasaka T, Kinoshita T, Kuno M, Seki N, Tanaka K, Nakanishi I, J Med Chem. 2004 Jul 15;47(15):3730-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15239652 15239652]
 [[Category: Adenosine deaminase]]
 [[Category: Bos taurus]]
@@ Line 20: / Line 29: @@
 [[Category: zinc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:13:45 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:06:10 2008''