1o7d: Difference between revisions
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{{STRUCTURE_1o7d| PDB=1o7d | SCENE= }} | {{STRUCTURE_1o7d| PDB=1o7d | SCENE= }} | ||
===THE STRUCTURE OF THE BOVINE LYSOSOMAL A-MANNOSIDASE SUGGESTS A NOVEL MECHANISM FOR LOW PH ACTIVATION=== | |||
{{ABSTRACT_PUBMED_12634058}} | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/MA2B1_BOVIN MA2B1_BOVIN]] Note=Defects in MAN2B1 are the cause of lysosomal alpha-mannosidosis (AM). AM is a lysosomal storage disease characterized by accumulation of unbranched oligosaccharide chains. The disease manifests itself by head tremor, aggressive tendency, ataxia, failure to thrive, and early death. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MA2B1_BOVIN MA2B1_BOVIN]] Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012634058</ref><references group="xtra"/> | <ref group="xtra">PMID:012634058</ref><references group="xtra"/><references/> | ||
[[Category: Alpha-mannosidase]] | [[Category: Alpha-mannosidase]] | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
Revision as of 06:15, 25 March 2013
THE STRUCTURE OF THE BOVINE LYSOSOMAL A-MANNOSIDASE SUGGESTS A NOVEL MECHANISM FOR LOW PH ACTIVATION
Template:ABSTRACT PUBMED 12634058
Disease
[MA2B1_BOVIN] Note=Defects in MAN2B1 are the cause of lysosomal alpha-mannosidosis (AM). AM is a lysosomal storage disease characterized by accumulation of unbranched oligosaccharide chains. The disease manifests itself by head tremor, aggressive tendency, ataxia, failure to thrive, and early death.
Function
[MA2B1_BOVIN] Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.
About this Structure
1o7d is a 5 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.
See Also
Reference
- Heikinheimo P, Helland R, Leiros HK, Leiros I, Karlsen S, Evjen G, Ravelli R, Schoehn G, Ruigrok R, Tollersrud OK, McSweeney S, Hough E. The structure of bovine lysosomal alpha-mannosidase suggests a novel mechanism for low-pH activation. J Mol Biol. 2003 Mar 28;327(3):631-44. PMID:12634058
