3hon: Difference between revisions
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{{STRUCTURE_3hon| PDB=3hon | SCENE= }} | {{STRUCTURE_3hon| PDB=3hon | SCENE= }} | ||
===Crystal Structure of Human Collagen XVIII Trimerization Domain (cubic form)=== | |||
{{ABSTRACT_PUBMED_19631658}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN]] Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1) [MIM:[http://omim.org/entry/267750 267750]]. An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.<ref>PMID:10942434</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN]] COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019631658</ref><references group="xtra"/> | <ref group="xtra">PMID:019631658</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bachinger, H P.]] | [[Category: Bachinger, H P.]] | ||
