1dn7: Difference between revisions
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==THE CRYSTAL STRUCTURE OF D(*G-G-G-G-C-C-C-C). A MODEL FOR POLY(D*G)(DOT)POLY(D*C)== | |||
<StructureSection load='1dn7' size='340' side='right' caption='[[1dn7]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DN7 FirstGlance]. <br> | |||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dn7 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1dn7 PDBsum]</span></td></tr> | |||
<table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The structure of the DNA oligomer d(G-G-G-G-C-C-C-C) has been determined at a resolution of 2.5 A by single-crystal X-ray methods. There are two strands in the asymmetric unit, and these coil about each other to form a right-handed double-helix of the A-type with Watson-Crick hydrogen bonds between base-pairs. The helix has a shallow minor groove and a deep, water-filled major groove; almost all exposed functional groups on the DNA are hydrated, and 106 ordered solvent molecules have been found. The two d(G-G-G-G).d(C-C-C-C) segments in the octamer exhibit similar and uniform structures, but there is a slight discontinuity at the GpC step between them. A recurring feature of the structure is the overlap of adjacent guanine bases in each GpG step, with the five-membered ring of one guanine stacking on the six-membered ring of its neighbour. There is little or no overlap between adjacent cytosine rings. Conformational parameters for these GpG steps are compared with those from other single-crystal X-ray analyses. In general, GpG steps exhibit high slide, low roll and variable twist. Models for poly(dG).poly(dC) were generated by applying a simple rotation and translation to each of the unmodified d(G-G-G-G).d(C-C-C-C) units. Detailed features of these models are shown to be compatible with various assays of poly(dG).poly(dC) in solution, and are useful in understanding the polymorphic behaviour of this sequence under a variety of experimental conditions. | |||
The crystal structure of d(G-G-G-G-C-C-C-C). A model for poly(dG).poly(dC).,McCall M, Brown T, Kennard O J Mol Biol. 1985 Jun 5;183(3):385-96. PMID:4020865<ref>PMID:4020865</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
< | |||
[[Category: Brown, T]] | [[Category: Brown, T]] | ||
[[Category: Kennard, O]] | [[Category: Kennard, O]] | ||
[[Category: Mccall, M J]] | [[Category: Mccall, M J]] | ||
Revision as of 06:44, 4 September 2014
THE CRYSTAL STRUCTURE OF D(*G-G-G-G-C-C-C-C). A MODEL FOR POLY(D*G)(DOT)POLY(D*C)
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