1ohj: Difference between revisions

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[[Image:1ohj.gif|left|200px]]<br /><applet load="1ohj" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ohj.gif|left|200px]]
caption="1ohj, resolution 2.50&Aring;" />
 
'''HUMAN DIHYDROFOLATE REDUCTASE, MONOCLINIC (P21) CRYSTAL FORM'''<br />
{{Structure
|PDB= 1ohj |SIZE=350|CAPTION= <scene name='initialview01'>1ohj</scene>, resolution 2.50&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=COP:N-(4-CARBOXY-4-{4-[(2,4-DIAMINO-PTERIDIN-6-YLMETHYL)-AMINO]-BENZOYLAMINO}-BUTYL)-PHTHALAMIC ACID'>COP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]
|GENE= POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''HUMAN DIHYDROFOLATE REDUCTASE, MONOCLINIC (P21) CRYSTAL FORM'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1OHJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NDP:'>NDP</scene> and <scene name='pdbligand=COP:'>COP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OHJ OCA].  
1OHJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OHJ OCA].  


==Reference==
==Reference==
Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523., Cody V, Galitsky N, Luft JR, Pangborn W, Rosowsky A, Blakley RL, Biochemistry. 1997 Nov 11;36(45):13897-903. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9374868 9374868]
Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523., Cody V, Galitsky N, Luft JR, Pangborn W, Rosowsky A, Blakley RL, Biochemistry. 1997 Nov 11;36(45):13897-903. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9374868 9374868]
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: oxidoreductase]]
[[Category: oxidoreductase]]


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