1scg: Difference between revisions

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~~{{Theoretical_model}}~~

==PAIR OF THEORETICAL MODELS FOR THE S. CEREVISIAE G PROTEIN HETEROTRIMER, BASED ON THE COORDINATES OF THE MAMMALIAN G PROTEIN==

== Structural highlights ==

<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SCG FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1scg FirstGlance], [http://www.ebi.ac.uk/pdbsum/1scg PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

The crystallographic structure of the G protein heterotrimer Gi alpha 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha and beta, an extended interface between beta and nearly all of gamma, and limited interaction of alpha with gamma. The major alpha/beta interface covers switch II of alpha, and GTP-induced rearrangement of switch II causes subunit dissociation during signaling. Alterations in GDP binding in the heterotrimer (compared with alpha-GDP) explain stabilization of the inactive conformation of alpha by beta gamma. Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade.

~~[[Image~~:~~1scg~~.~~png|left|200px]]~~

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.,Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR Cell. 1995 Dec 15;83(6):1047-58. PMID:8521505<ref>PMID:8521505</ref>

~~{{STRUCTURE_1scg| PDB=1scg | SCENE= }}~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~===PAIR OF THEORETICAL MODELS FOR THE~~ S. ~~CEREVISIAE G PROTEIN HETEROTRIMER, BASED ON THE COORDINATES OF THE MAMMALIAN G PROTEIN===~~

== References ==

~~{{ABSTRACT_PUBMED_8521505}}~~

__TOC__

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:008521505<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Gaitatzes, C G]]

[[Category: Neer, E J]]

[[Category: Smith, T F]]

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@@ Line 1: / Line 1: @@
-{{Theoretical_model}}
+==PAIR OF THEORETICAL MODELS FOR THE S. CEREVISIAE G PROTEIN HETEROTRIMER, BASED ON THE COORDINATES OF THE MAMMALIAN G PROTEIN==
+<StructureSection load='1scg' size='340' side='right' caption='[[1scg]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SCG FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1scg FirstGlance], [http://www.ebi.ac.uk/pdbsum/1scg PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The crystallographic structure of the G protein heterotrimer Gi alpha 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha and beta, an extended interface between beta and nearly all of gamma, and limited interaction of alpha with gamma. The major alpha/beta interface covers switch II of alpha, and GTP-induced rearrangement of switch II causes subunit dissociation during signaling. Alterations in GDP binding in the heterotrimer (compared with alpha-GDP) explain stabilization of the inactive conformation of alpha by beta gamma. Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade.
-[[Image:1scg.png|left|200px]]
+The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.,Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR Cell. 1995 Dec 15;83(6):1047-58. PMID:8521505<ref>PMID:8521505</ref>
-{{STRUCTURE_1scg|  PDB=1scg  |  SCENE=  }}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-===PAIR OF THEORETICAL MODELS FOR THE S. CEREVISIAE G PROTEIN HETEROTRIMER, BASED ON THE COORDINATES OF THE MAMMALIAN G PROTEIN===
+== References ==
+<references/>
-{{ABSTRACT_PUBMED_8521505}}
+__TOC__
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:008521505</ref><references group="xtra"/>
 [[Category: Gaitatzes, C G]]
 [[Category: Neer, E J]]
 [[Category: Smith, T F]]