1afx: Difference between revisions

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[[~~Image~~:1afx.~~png|left|200px~~]]

==UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES==

== Structural highlights ==

<table><tr><td colspan='2'>[[1afx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AFX FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1afx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1afx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1afx RCSB], [http://www.ebi.ac.uk/pdbsum/1afx PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

The hairpin ribozyme is a small catalytic RNA with a unique two-domain structure. Here we present the solution structure of the loop B domain of the hairpin ribozyme, which contains most of the catalytically essential nucleotides. The 38-nucleotide domain contains a 16-nucleotide internal loop that forms one of the largest non-Watson-Crick segments of base pairing thus far determined by either NMR or crystallography. Since the solution structure of the smaller loop A domain has been previously solved, an NMR structure-based model of the 22,000 Mr hairpin ribozyme-substrate open complex emerges by joining the two domain structures. Strikingly, catalytically essential functional groups for the loop B domain are concentrated within an expanded minor groove, presenting a clear docking surface for the loop A domain.

~~{{STRUCTURE_1afx| PDB=1afx | SCENE= }}~~

Solution structure of the loop B domain from the hairpin ribozyme.,Butcher SE, Allain FH, Feigon J Nat Struct Biol. 1999 Mar;6(3):212-6. PMID:10074938<ref>PMID:10074938</ref>

~~===UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR~~, ~~13 STRUCTURES===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_10074938}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[1afx]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1AFX OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:010074938<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Butcher, S E.]]

[[Category: Dieckmann, T.]]

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-[[Image:1afx.png|left|200px]]
+==UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES==
+<StructureSection load='1afx' size='340' side='right' caption='[[1afx]], [[NMR_Ensembles_of_Models | 13 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1afx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AFX FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1afx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1afx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1afx RCSB], [http://www.ebi.ac.uk/pdbsum/1afx PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The hairpin ribozyme is a small catalytic RNA with a unique two-domain structure. Here we present the solution structure of the loop B domain of the hairpin ribozyme, which contains most of the catalytically essential nucleotides. The 38-nucleotide domain contains a 16-nucleotide internal loop that forms one of the largest non-Watson-Crick segments of base pairing thus far determined by either NMR or crystallography. Since the solution structure of the smaller loop A domain has been previously solved, an NMR structure-based model of the 22,000 Mr hairpin ribozyme-substrate open complex emerges by joining the two domain structures. Strikingly, catalytically essential functional groups for the loop B domain are concentrated within an expanded minor groove, presenting a clear docking surface for the loop A domain.
-{{STRUCTURE_1afx|  PDB=1afx  |  SCENE=  }}
+Solution structure of the loop B domain from the hairpin ribozyme.,Butcher SE, Allain FH, Feigon J Nat Struct Biol. 1999 Mar;6(3):212-6. PMID:10074938<ref>PMID:10074938</ref>
-===UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_10074938}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1afx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFX OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:010074938</ref><references group="xtra"/>
 [[Category: Butcher, S E.]]
 [[Category: Dieckmann, T.]]