1a1q: Difference between revisions

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[[~~Image~~:~~1a1q~~.~~png~~|~~left~~|~~200px~~]]

==HEPATITIS C VIRUS NS3 PROTEINASE==

== Structural highlights ==

<table><tr><td colspan='2'>[[1a1q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A1Q FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>

<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])</td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a1q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a1q RCSB], [http://www.ebi.ac.uk/pdbsum/1a1q PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

During replication of hepatitis C virus (HCV), the final steps of polyprotein processing are performed by a viral proteinase located in the N-terminal one-third of nonstructural protein 3. The structure of NS3 proteinase from HCV BK strain was determined by X-ray crystallography at 2.4 angstrom resolution. NS3P folds as a trypsin-like proteinase with two beta barrels and a catalytic triad of His-57, Asp-81, Ser-139. The structure has a substrate-binding site consistent with the cleavage specificity of the enzyme. Novel features include a structural zinc-binding site and a long N-terminus that interacts with neighboring molecules by binding to a hydrophobic surface patch.

~~{{STRUCTURE_1a1q| PDB=1a1q | SCENE= }}~~

The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site.,Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, Adachi T, Hostomska Z Cell. 1996 Oct 18;87(2):331-42. PMID:8861916<ref>PMID:8861916</ref>

~~===HEPATITIS C VIRUS NS3 PROTEINASE===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_8861916}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[1a1q]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Hepatitis_c_virus Hepatitis c virus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1A1Q OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:008861916<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Hepatitis c virus]]

[[Category: Adachi, T.]]

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@@ Line 1: / Line 1: @@
-[[Image:1a1q.png|left|200px]]
+==HEPATITIS C VIRUS NS3 PROTEINASE==
+<StructureSection load='1a1q' size='340' side='right' caption='[[1a1q]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1a1q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A1Q FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
+<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a1q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1a1q RCSB], [http://www.ebi.ac.uk/pdbsum/1a1q PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+During replication of hepatitis C virus (HCV), the final steps of polyprotein processing are performed by a viral proteinase located in the N-terminal one-third of nonstructural protein 3. The structure of NS3 proteinase from HCV BK strain was determined by X-ray crystallography at 2.4 angstrom resolution. NS3P folds as a trypsin-like proteinase with two beta barrels and a catalytic triad of His-57, Asp-81, Ser-139. The structure has a substrate-binding site consistent with the cleavage specificity of the enzyme. Novel features include a structural zinc-binding site and a long N-terminus that interacts with neighboring molecules by binding to a hydrophobic surface patch.
-{{STRUCTURE_1a1q|  PDB=1a1q  |  SCENE=  }}
+The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site.,Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, Adachi T, Hostomska Z Cell. 1996 Oct 18;87(2):331-42. PMID:8861916<ref>PMID:8861916</ref>
-===HEPATITIS C VIRUS NS3 PROTEINASE===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_8861916}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1a1q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1Q OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:008861916</ref><references group="xtra"/>
 [[Category: Hepatitis c virus]]
 [[Category: Adachi, T.]]