1an4: Difference between revisions
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{{STRUCTURE_1an4| PDB=1an4 | SCENE= }} | {{STRUCTURE_1an4| PDB=1an4 | SCENE= }} | ||
===STRUCTURE AND FUNCTION OF THE B/HLH/Z DOMAIN OF USF=== | |||
{{ABSTRACT_PUBMED_8306960}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/USF1_HUMAN USF1_HUMAN]] Genetic variations in USF1 are associated with hyperlipidemia combined type 1 (HYPLIP1) [MIM:[http://omim.org/entry/602491 602491]]; also known as familial combined hyperlipidemia type 1 (FCHL1). HYPLIP1 is characterized by elevated levels of serum total cholesterol, triglycerides or both, and is observed in about 20% of individuals with premature coronary heart disease.<ref>PMID:14991056</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/USF1_HUMAN USF1_HUMAN]] Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:008306960</ref><ref group="xtra">PMID:011258480</ref><references group="xtra"/> | <ref group="xtra">PMID:008306960</ref><ref group="xtra">PMID:011258480</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Amare, A R.Ferre-D.]] | [[Category: Amare, A R.Ferre-D.]] | ||
