1b66: Difference between revisions
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{{STRUCTURE_1b66| PDB=1b66 | SCENE= }} | {{STRUCTURE_1b66| PDB=1b66 | SCENE= }} | ||
===6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE=== | |||
{{ABSTRACT_PUBMED_10024455}} | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/PTPS_RAT PTPS_RAT]] Note=Deficiency leads to phenylketonuria. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PTPS_RAT PTPS_RAT]] Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:010024455</ref><ref group="xtra">PMID:010737935</ref><references group="xtra"/> | <ref group="xtra">PMID:010024455</ref><ref group="xtra">PMID:010737935</ref><references group="xtra"/><references/> | ||
[[Category: 6-pyruvoyltetrahydropterin synthase]] | [[Category: 6-pyruvoyltetrahydropterin synthase]] | ||
[[Category: Rattus rattus]] | [[Category: Rattus rattus]] | ||
Revision as of 04:00, 25 March 2013
6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE
Template:ABSTRACT PUBMED 10024455
Disease
[PTPS_RAT] Note=Deficiency leads to phenylketonuria.
Function
[PTPS_RAT] Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
About this Structure
1b66 is a 2 chain structure with sequence from Rattus rattus. Full crystallographic information is available from OCA.
Reference
- Ploom T, Thony B, Yim J, Lee S, Nar H, Leimbacher W, Richardson J, Huber R, Auerbach G. Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase. J Mol Biol. 1999 Feb 26;286(3):851-60. PMID:10024455 doi:10.1006/jmbi.1998.2511
- Colloc'h N, Poupon A, Mornon JP. Sequence and structural features of the T-fold, an original tunnelling building unit. Proteins. 2000 May 1;39(2):142-54. PMID:10737935
