1osp: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1osp.gif|left|200px]] | [[Image:1osp.gif|left|200px]] | ||
'''CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN A OF BORRELIA BURGDORFERI COMPLEXED WITH A MURINE MONOCLONAL ANTIBODY FAB''' | {{Structure | ||
|PDB= 1osp |SIZE=350|CAPTION= <scene name='initialview01'>1osp</scene>, resolution 1.95Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN A OF BORRELIA BURGDORFERI COMPLEXED WITH A MURINE MONOCLONAL ANTIBODY FAB''' | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
1OSP is a [ | 1OSP is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSP OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab., Li H, Dunn JJ, Luft BJ, Lawson CL, Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3584-9. PMID:[http:// | Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab., Li H, Dunn JJ, Luft BJ, Lawson CL, Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3584-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9108020 9108020] | ||
[[Category: Borrelia burgdorferi]] | [[Category: Borrelia burgdorferi]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| Line 20: | Line 29: | ||
[[Category: outer surface protein a complexed with fab184 1]] | [[Category: outer surface protein a complexed with fab184 1]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:15:04 2008'' | ||
Revision as of 11:15, 20 March 2008
| |||||||||||||
| 1osp, resolution 1.95Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN A OF BORRELIA BURGDORFERI COMPLEXED WITH A MURINE MONOCLONAL ANTIBODY FAB
Overview
OspA (outer surface protein A) is an abundant immunogenic lipoprotein of the Lyme disease spirochete Borrelia burgdorferi. The crystal structure of a soluble recombinant form of OspA was solved in a complex with the Fab fragment of mouse monoclonal antibody 184.1 and refined to a resolution of 1.9 A. OspA has a repetitive antiparallel beta topology with an unusual nonglobular region of "freestanding" sheet connecting globular N- and C-terminal domains. Arrays of residues with alternating charges are a predominant feature of the folding pattern in the nonglobular region. The 184.1 epitope overlaps with a well conserved surface in the N-terminal domain, and a hydrophobic cavity buried in a positively charged cleft in the C-terminal domain is a potential binding site for an unknown ligand. An exposed variable region on the C-terminal domain of OspA is predicted to be an important factor in the worldwide effectiveness of OspA-based vaccines.
About this Structure
1OSP is a Protein complex structure of sequences from Borrelia burgdorferi and Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab., Li H, Dunn JJ, Luft BJ, Lawson CL, Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3584-9. PMID:9108020
Page seeded by OCA on Thu Mar 20 13:15:04 2008
