1c7u: Difference between revisions

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~~[[Image:1c7u.png|left|200px]]~~

===Complex of the DNA binding core domain of the transcription factor MEF2A with a 20mer oligonucleotide===

===~~Complex~~ of the ~~DNA binding core domain of~~ the ~~transcription factor MEF2A with a 20mer oligonucleotide===~~

==Disease==

[[http://www.uniprot.org/uniprot/MEF2A_HUMAN MEF2A_HUMAN]] Defects in MEF2A are a cause of coronary artery disease, autosomal dominant, type 1 (ADCAD1) [MIM:[http://omim.org/entry/608320 608320]]. A common heart disease characterized by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart. Its most important complication is acute myocardial infarction.

~~{{ABSTRACT_PUBMED_10835359}}~~

==Function==

[[http://www.uniprot.org/uniprot/MEF2A_HUMAN MEF2A_HUMAN]] Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.<ref>PMID:9858528</ref><ref>PMID:11904443</ref><ref>PMID:12691662</ref><ref>PMID:15834131</ref><ref>PMID:16563226</ref><ref>PMID:16371476</ref><ref>PMID:16484498</ref>

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Clore, G M.]]

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@@ Line 1: / Line 1: @@
-[[Image:1c7u.png|left|200px]]
 {{STRUCTURE_1c7u|  PDB=1c7u  |  SCENE=  }}
+===Complex of the DNA binding core domain of the transcription factor MEF2A with a 20mer oligonucleotide===
+{{ABSTRACT_PUBMED_10835359}}
-===Complex of the DNA binding core domain of the transcription factor MEF2A with a 20mer oligonucleotide===
+==Disease==
+[[http://www.uniprot.org/uniprot/MEF2A_HUMAN MEF2A_HUMAN]] Defects in MEF2A are a cause of coronary artery disease, autosomal dominant, type 1 (ADCAD1) [MIM:[http://omim.org/entry/608320 608320]]. A common heart disease characterized by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart. Its most important complication is acute myocardial infarction.
-{{ABSTRACT_PUBMED_10835359}}
+==Function==
+[[http://www.uniprot.org/uniprot/MEF2A_HUMAN MEF2A_HUMAN]] Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.<ref>PMID:9858528</ref><ref>PMID:11904443</ref><ref>PMID:12691662</ref><ref>PMID:15834131</ref><ref>PMID:16563226</ref><ref>PMID:16371476</ref><ref>PMID:16484498</ref>
 ==About this Structure==
@@ Line 11: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:010835359</ref><references group="xtra"/>
+<ref group="xtra">PMID:010835359</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Clore, G M.]]