1ddf: Difference between revisions

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~~[[Image:1ddf.png|left|200px]]~~

===FAS DEATH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE===

===FAS ~~DEATH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE===~~

==Disease==

[[http://www.uniprot.org/uniprot/TNR6_HUMAN TNR6_HUMAN]] Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:[http://omim.org/entry/601859 601859]]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.<ref>PMID:17336828</ref><ref>PMID:7540117</ref><ref>PMID:8929361</ref><ref>PMID:9028321</ref><ref>PMID:9028957</ref><ref>PMID:9322534</ref><ref>PMID:9821419</ref><ref>PMID:10090885</ref><ref>PMID:10515860</ref><ref>PMID:10340403</ref><ref>PMID:9927496</ref><ref>PMID:11418480</ref><ref>PMID:20935634</ref>

~~{{ABSTRACT_PUBMED_8967952}}~~

==Function==

[[http://www.uniprot.org/uniprot/TNR6_HUMAN TNR6_HUMAN]] Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).<ref>PMID:7533181</ref><ref>PMID:19118384</ref>

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Eberstadt, M.]]

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@@ Line 1: / Line 1: @@
-[[Image:1ddf.png|left|200px]]
 {{STRUCTURE_1ddf|  PDB=1ddf  |  SCENE=  }}
+===FAS DEATH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE===
+{{ABSTRACT_PUBMED_8967952}}
-===FAS DEATH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE===
+==Disease==
+[[http://www.uniprot.org/uniprot/TNR6_HUMAN TNR6_HUMAN]] Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:[http://omim.org/entry/601859 601859]]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.<ref>PMID:17336828</ref><ref>PMID:7540117</ref><ref>PMID:8929361</ref><ref>PMID:9028321</ref><ref>PMID:9028957</ref><ref>PMID:9322534</ref><ref>PMID:9821419</ref><ref>PMID:10090885</ref><ref>PMID:10515860</ref><ref>PMID:10340403</ref><ref>PMID:9927496</ref><ref>PMID:11418480</ref><ref>PMID:20935634</ref>
-{{ABSTRACT_PUBMED_8967952}}
+==Function==
+[[http://www.uniprot.org/uniprot/TNR6_HUMAN TNR6_HUMAN]] Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).<ref>PMID:7533181</ref><ref>PMID:19118384</ref>
 ==About this Structure==
@@ Line 11: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:008967952</ref><ref group="xtra">PMID:011742118</ref><references group="xtra"/>
+<ref group="xtra">PMID:008967952</ref><ref group="xtra">PMID:011742118</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Eberstadt, M.]]