1d24: Difference between revisions

Line 1:

[[~~Image~~:1d24.~~png|~~left~~|200px]~~]

==CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE==

== Structural highlights ==

<table><tr><td colspan='2'>[[1d24]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D24 FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene></td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d24 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d24 RCSB], [http://www.ebi.ac.uk/pdbsum/1d24 PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

The crystal and molecular structure of the first DNA duplex containing the carcinogenic lesion O6MeG has been determined to a resolution of 1.9 A and refined to an R factor of 19%. (d[CGC-(O6Me)GCG])2 crystallizes in the left-handed Z DNA form and has crystal parameters and conformational features similar to those of the parent sequence [d(CG)3]2. The methyl groups on O6 of G4 and G10 have C5-C6-O6-O6Me torsion angles of 73 degrees and 56 degrees, respectively, and protrude onto the major groove surface. The base-pairing conformation for the methylated G.C base pairs is of the Watson-Crick type as opposed to a wobble-type conformation that had been proposed in a B DNA fragment. As in other Z DNA structures, a spine of hydration is seen in the minor groove.

~~{{STRUCTURE_1d24| PDB=1d24 | SCENE= }}~~

Crystal and molecular structure of a DNA duplex containing the carcinogenic lesion O6-methylguanine.,Ginell SL, Kuzmich S, Jones RA, Berman HM Biochemistry. 1990 Nov 20;29(46):10461-5. PMID:2271657<ref>PMID:2271657</ref>

~~===CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_2271657}}~~

== References ==

==~~About this Structure~~==

__TOC__

~~[[1d24]] is a 2 chain structure. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=1D24 OCA].~~

</StructureSection>

[[Category: Berman, H M.]]

[[Category: Ginell, S L.]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1d24.png|left|200px]]
+==CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE==
+<StructureSection load='1d24' size='340' side='right' caption='[[1d24]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1d24]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D24 FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d24 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d24 RCSB], [http://www.ebi.ac.uk/pdbsum/1d24 PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The crystal and molecular structure of the first DNA duplex containing the carcinogenic lesion O6MeG has been determined to a resolution of 1.9 A and refined to an R factor of 19%. (d[CGC-(O6Me)GCG])2 crystallizes in the left-handed Z DNA form and has crystal parameters and conformational features similar to those of the parent sequence [d(CG)3]2. The methyl groups on O6 of G4 and G10 have C5-C6-O6-O6Me torsion angles of 73 degrees and 56 degrees, respectively, and protrude onto the major groove surface. The base-pairing conformation for the methylated G.C base pairs is of the Watson-Crick type as opposed to a wobble-type conformation that had been proposed in a B DNA fragment. As in other Z DNA structures, a spine of hydration is seen in the minor groove.
-{{STRUCTURE_1d24|  PDB=1d24  |  SCENE=  }}
+Crystal and molecular structure of a DNA duplex containing the carcinogenic lesion O6-methylguanine.,Ginell SL, Kuzmich S, Jones RA, Berman HM Biochemistry. 1990 Nov 20;29(46):10461-5. PMID:2271657<ref>PMID:2271657</ref>
-===CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_2271657}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1d24]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D24 OCA].
+</StructureSection>
 [[Category: Berman, H M.]]
 [[Category: Ginell, S L.]]