1cq3: Difference between revisions

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[[Image:1cq3.png|left|200px]]
==STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS==
<StructureSection load='1cq3' size='340' side='right' caption='[[1cq3]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1cq3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cowpox_virus Cowpox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CQ3 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cq3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cq3 RCSB], [http://www.ebi.ac.uk/pdbsum/1cq3 PDBsum]</span></td></tr>
<table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/1cq3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Most poxviruses, including variola, the causative agent of smallpox, express a secreted protein of 35 kDa, vCCI, which binds CC-chemokines with high affinity. This viral protein competes with the host cellular CC-chemokine receptors (CCRs), reducing inflammation and interfering with the host immune response. Such proteins or derivatives may have therapeutic uses as anti-inflammatory agents. We have determined the crystal structure to 1.85-A resolution of vCCI from cowpox virus, the prototype of this poxvirus virulence factor. The molecule is a beta-sandwich of topology not previously described. A patch of conserved residues on the exposed face of a beta-sheet that is strongly negatively charged might have a role in binding of CC-chemokines, which are positively charged.


{{STRUCTURE_1cq3|  PDB=1cq3  |  SCENE=  }}
Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus.,Carfi A, Smith CA, Smolak PJ, McGrew J, Wiley DC Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12379-83. PMID:10535930<ref>PMID:10535930</ref>


===STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_10535930}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[1cq3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cowpox_virus Cowpox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQ3 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:010535930</ref><ref group="xtra">PMID:011880627</ref><references group="xtra"/>
[[Category: Cowpox virus]]
[[Category: Cowpox virus]]
[[Category: Carfi, A.]]
[[Category: Carfi, A.]]
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