Anthrax Lethal Factor: Difference between revisions
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{{STRUCTURE_1j7n| PDB=1j7n | SIZE=500| SCENE= |right|CAPTION=Anthrax toxin lethal factor dimer complex with sulfate and Zn+2 ions [[1j7n]] }} | {{STRUCTURE_1j7n| PDB=1j7n | SIZE=500| SCENE= |right|CAPTION=Anthrax toxin lethal factor dimer complex with sulfate and Zn+2 ions [[1j7n]] }} | ||
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==Introduction== | ==Introduction== | ||
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PA+LF+EF Leads to lethal activity and edema | PA+LF+EF Leads to lethal activity and edema | ||
<StructureSection load="1j7n" size="600" color="" frame="true" spin="on" Scene ="" align="right" caption=""> | |||
==Human Interaction== | ==Human Interaction== | ||
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The most will known case of biological warfare in recent times occurred in 2001, known as [http://en.wikipedia.org/wiki/2001_anthrax_attacks Amerithrax]. Anthrax spores are a top choice for biological warfare because their potency. Production of these spores are among the easiest of bioterror agents. <ref>Brenda A. Wilson, Abigail A. Salyers, Dixie D. Whitt, and Malcolm E. Winkler. Third Edition. Bacterial Pathogenesis A Molecular Approach</ref> They can be manipulated and produced in large quantities using basic microbiology techniques. Naturally occurring spores tend to aggregate making them less infection; they can easily be refined and dispersed. Because the anthrax spores are very robust; being able to survive for decades and are difficult to destroy, makes them excellent bioweapons. <ref>Brenda A. Wilson, Abigail A. Salyers, Dixie D. Whitt, and Malcolm E. Winkler. Third Edition. Bacterial Pathogenesis A Molecular Approach</ref> <ref>Kenneth Todar, PhD. (2008). http://textbookofbacteriology.net/Anthrax_3.html</ref> | The most will known case of biological warfare in recent times occurred in 2001, known as [http://en.wikipedia.org/wiki/2001_anthrax_attacks Amerithrax]. Anthrax spores are a top choice for biological warfare because their potency. Production of these spores are among the easiest of bioterror agents. <ref>Brenda A. Wilson, Abigail A. Salyers, Dixie D. Whitt, and Malcolm E. Winkler. Third Edition. Bacterial Pathogenesis A Molecular Approach</ref> They can be manipulated and produced in large quantities using basic microbiology techniques. Naturally occurring spores tend to aggregate making them less infection; they can easily be refined and dispersed. Because the anthrax spores are very robust; being able to survive for decades and are difficult to destroy, makes them excellent bioweapons. <ref>Brenda A. Wilson, Abigail A. Salyers, Dixie D. Whitt, and Malcolm E. Winkler. Third Edition. Bacterial Pathogenesis A Molecular Approach</ref> <ref>Kenneth Todar, PhD. (2008). http://textbookofbacteriology.net/Anthrax_3.html</ref> | ||
</StructureSection> | |||
== 3D structures of anthrax lethal factor== | == 3D structures of anthrax lethal factor== | ||
