3kq4: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3kq4| PDB=3kq4 | SCENE= }} | {{STRUCTURE_3kq4| PDB=3kq4 | SCENE= }} | ||
===Structure of Intrinsic Factor-Cobalamin bound to its receptor Cubilin=== | |||
{{ABSTRACT_PUBMED_20237569}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/IF_HUMAN IF_HUMAN]] Defects in GIF are the cause of hereditary intrinsic factor deficiency (IFD) [MIM:[http://omim.org/entry/261000 261000]]; also known as congenital pernicious anemia. IFD is an autosomal recessive disorder characterized by megaloblastic anemia.<ref>PMID:15738392</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IF_HUMAN IF_HUMAN]] Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis. | |||
==About this Structure== | ==About this Structure== | ||
| Line 11: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020237569</ref><references group="xtra"/> | <ref group="xtra">PMID:020237569</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Andersen, C B.F.]] | [[Category: Andersen, C B.F.]] | ||
