2pmv: Difference between revisions
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{{STRUCTURE_2pmv| PDB=2pmv | SCENE= }} | {{STRUCTURE_2pmv| PDB=2pmv | SCENE= }} | ||
===Crystal Structure of Human Intrinsic Factor- Cobalamin Complex at 2.6 A Resolution=== | |||
{{ABSTRACT_PUBMED_17954916}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/IF_HUMAN IF_HUMAN]] Defects in GIF are the cause of hereditary intrinsic factor deficiency (IFD) [MIM:[http://omim.org/entry/261000 261000]]; also known as congenital pernicious anemia. IFD is an autosomal recessive disorder characterized by megaloblastic anemia.<ref>PMID:15738392</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IF_HUMAN IF_HUMAN]] Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017954916</ref><references group="xtra"/> | <ref group="xtra">PMID:017954916</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Alpers, D H.]] | [[Category: Alpers, D H.]] | ||
