4a3n: Difference between revisions

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~~[[Image:4a3n.png|left|200px]]~~

===Crystal Structure of HMG-BOX of Human SOX17===

===~~Crystal Structure~~ of ~~HMG~~-~~BOX of Human SOX17===~~

==Disease==

[[http://www.uniprot.org/uniprot/SOX17_HUMAN SOX17_HUMAN]] Defects in SOX17 are the cause of vesicoureteral reflux type 3 (VUR3) [MIM:[http://omim.org/entry/613674 613674]]. VUR3 is a disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.<ref>PMID:20960469</ref>

~~{{ABSTRACT_PUBMED_23061670}}~~

==Function==

[[http://www.uniprot.org/uniprot/SOX17_HUMAN SOX17_HUMAN]] Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity).

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Gao, H.]]

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-[[Image:4a3n.png|left|200px]]
 {{STRUCTURE_4a3n|  PDB=4a3n  |  SCENE=  }}
+===Crystal Structure of HMG-BOX of Human SOX17===
+{{ABSTRACT_PUBMED_23061670}}
-===Crystal Structure of HMG-BOX of Human SOX17===
+==Disease==
+[[http://www.uniprot.org/uniprot/SOX17_HUMAN SOX17_HUMAN]] Defects in SOX17 are the cause of vesicoureteral reflux type 3 (VUR3) [MIM:[http://omim.org/entry/613674 613674]]. VUR3 is a disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.<ref>PMID:20960469</ref>
-{{ABSTRACT_PUBMED_23061670}}
+==Function==
+[[http://www.uniprot.org/uniprot/SOX17_HUMAN SOX17_HUMAN]] Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity).
 ==About this Structure==
@@ Line 11: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:019328208</ref><references group="xtra"/>
+<ref group="xtra">PMID:019328208</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Gao, H.]]