4h5s: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Complex structure of Necl-2 and CRTAM===

~~The entry 4h5s~~ is ~~ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/CRTAM_HUMAN CRTAM_HUMAN]] Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.<ref>PMID:15811952</ref> [UniProtKB:Q149L7] [[http://www.uniprot.org/uniprot/CADM1_HUMAN CADM1_HUMAN]] Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.<ref>PMID:11279526</ref> <ref>PMID:12234973</ref> <ref>PMID:12050160</ref> <ref>PMID:12920246</ref> <ref>PMID:15811952</ref> <ref>PMID:15905536</ref> [UniProtKB:Q8R5M8]

~~Authors~~: ~~Zhang, S~~.~~, Lu, G~~.~~, Qi, J~~.~~, Li, Y., Zhang, Z., Zhang, B~~.~~, Yan, J~~.~~, Gao, G~~.F.

==About this Structure==

[[4h5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5S OCA].

~~Description~~: ~~Complex structure of Necl-2 and CRTAM~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Gao, G F.]]

[[Category: Li, Y.]]

[[Category: Lu, G.]]

[[Category: Qi, J.]]

[[Category: Yan, J.]]

[[Category: Zhang, B.]]

[[Category: Zhang, S.]]

[[Category: Zhang, Z.]]

[[Category: Cell adhesion]]

[[Category: Ig fold]]

[[Category: Immune recognition]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4h5s|  PDB=4h5s  |  SCENE=  }}
+===Complex structure of Necl-2 and CRTAM===
+{{ABSTRACT_PUBMED_23871486}}
-The entry 4h5s is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/CRTAM_HUMAN CRTAM_HUMAN]] Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.<ref>PMID:15811952</ref> [UniProtKB:Q149L7] [[http://www.uniprot.org/uniprot/CADM1_HUMAN CADM1_HUMAN]] Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.<ref>PMID:11279526</ref> <ref>PMID:12234973</ref> <ref>PMID:12050160</ref> <ref>PMID:12920246</ref> <ref>PMID:15811952</ref> <ref>PMID:15905536</ref> [UniProtKB:Q8R5M8]
-Authors: Zhang, S., Lu, G., Qi, J., Li, Y., Zhang, Z., Zhang, B., Yan, J., Gao, G.F.
+==About this Structure==
+[[4h5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5S OCA].
-Description: Complex structure of Necl-2 and CRTAM
+==Reference==
+<ref group="xtra">PMID:023871486</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Gao, G F.]]
+[[Category: Li, Y.]]
+[[Category: Lu, G.]]
+[[Category: Qi, J.]]
+[[Category: Yan, J.]]
+[[Category: Zhang, B.]]
+[[Category: Zhang, S.]]
+[[Category: Zhang, Z.]]
+[[Category: Cell adhesion]]
+[[Category: Ig fold]]
+[[Category: Immune recognition]]