4hhy: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of PARP catalytic domain in complex with novel inhibitors===

~~The entry 4hhy~~ is ~~ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref><ref>PMID:18172500</ref><ref>PMID:19344625</ref><ref>PMID:19661379</ref>

~~Authors~~: ~~Liu, Q~~.F.~~, Chen, T~~.T.~~, Xu, Y~~.C.

==About this Structure==

[[4hhy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHY OCA].

~~Description~~: ~~Crystal structure of PARP catalytic domain in~~ complex ~~with novel inhibitors~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Chen, T T.]]

[[Category: Liu, Q F.]]

[[Category: Xu, Y C.]]

[[Category: Polymerase]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4hhy|  PDB=4hhy  |  SCENE=  }}
+===Crystal structure of PARP catalytic domain in complex with novel inhibitors===
+{{ABSTRACT_PUBMED_23473053}}
-The entry 4hhy is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref><ref>PMID:18172500</ref><ref>PMID:19344625</ref><ref>PMID:19661379</ref>
-Authors: Liu, Q.F., Chen, T.T., Xu, Y.C.
+==About this Structure==
+[[4hhy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHY OCA].
-Description: Crystal structure of PARP catalytic domain in complex with novel inhibitors
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Chen, T T.]]
+[[Category: Liu, Q F.]]
+[[Category: Xu, Y C.]]
+[[Category: Polymerase]]
+[[Category: Transferase-transferase inhibitor complex]]