1p7q: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1p7q.jpg|left|200px]] | [[Image:1p7q.jpg|left|200px]] | ||
'''Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor''' | {{Structure | ||
|PDB= 1p7q |SIZE=350|CAPTION= <scene name='initialview01'>1p7q</scene>, resolution 3.40Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= HLA-A OR HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor''' | |||
==Overview== | ==Overview== | ||
| Line 10: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
1P7Q is a [ | 1P7Q is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7Q OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor., Willcox BE, Thomas LM, Bjorkman PJ, Nat Immunol. 2003 Sep;4(9):913-9. Epub 2003 Aug 3. PMID:[http:// | Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor., Willcox BE, Thomas LM, Bjorkman PJ, Nat Immunol. 2003 Sep;4(9):913-9. Epub 2003 Aug 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12897781 12897781] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| Line 21: | Line 30: | ||
[[Category: hla-a2/lir-1 complex]] | [[Category: hla-a2/lir-1 complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:20:59 2008'' | ||
Revision as of 11:21, 20 March 2008
| |||||||||||||
| 1p7q, resolution 3.40Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene: | HLA-A OR HLAA (Homo sapiens), B2M (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor
Overview
Leukocyte immunoglobulin-like receptor 1 (LIR-1), an inhibitory receptor expressed on monocytes, dendritic cells and lymphocytes, regulates cellular function by binding a broad range of classical and nonclassical major histocompatibility complex (MHC) class I molecules, and the human cytomegalovirus MHC class I homolog UL18. Here we describe the 3.4-A crystal structure of a complex between the LIR-1 D1D2 domains and the MHC class I molecule HLA-A2. LIR-1 contacts the mostly conserved beta(2)-microglobulin and alpha3 domains of HLA-A2. The LIR-1 binding site comprises residues at the interdomain hinge, and a patch at the D1 tip. The structure shows how LIR-1 recognizes UL18 and diverse MHC class I molecules, and indicates that a similar mode of MHC class I recognition is used by other LIR family members.
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this Structure
1P7Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor., Willcox BE, Thomas LM, Bjorkman PJ, Nat Immunol. 2003 Sep;4(9):913-9. Epub 2003 Aug 3. PMID:12897781
Page seeded by OCA on Thu Mar 20 13:20:59 2008
